Methylate

$70.00

Supports Healthy Homocysteine Metabolism^‡

$0.70/day · 90-day supply

Precision methylation support for healthy homocysteine metabolism, featuring triple-form B12, TMG, CDP-choline, L-5-MTHF, active B vitamins, and zinc — not a generic B-complex.^‡

Methylate is designed to support methylation pathways, healthy homocysteine metabolism, cellular energy metabolism, and healthy B12 status.^‡ TMG and CDP-choline provide methyl donor support through complementary pathways, while L-5-MTHF, B12, riboflavin, and P5P support folate- and B-vitamin-dependent methylation pathways.^‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational methylation support.

Per Serving

1200mcg DFE Folate (as L-5-MTHF)
1800mcg Vitamin B12 (as 600mcg Methylcobalamin, 600mcg Hydroxocobalamin, 600mcg Adenosylcobalamin)
15mg Riboflavin (as R5P)
10mg Vitamin B6 (as P5P)
5mg Zinc (as Zinc Bisglycinate)
750mg Trimethylglycine (TMG) (as Betaine Anhydrous)
200mg CDP-Choline (Citicoline)

How to Take

Take two (2) capsules daily, or as recommended by your healthcare professional.

The Science

Methylate was designed around nutrients involved in one-carbon metabolism, methylation pathways, and healthy homocysteine metabolism.^‡ Folate, B12, B6, and riboflavin support B-vitamin-dependent pathways, while TMG and CDP-choline provide methyl donor support through betaine-related pathways.^‡

Folate, B12, B6, and homocysteine metabolism
Review discussing folate, vitamin B12, and vitamin B6 as coenzymes involved in homocysteine metabolism.
PMID: 9587042
B vitamins and one-carbon metabolism
Review discussing folate, B12, B6, and B2 as coenzymes involved in one-carbon metabolism.
PMID: 11813080
TMG/betaine and methyl donor support
Review discussing betaine as a methyl donor involved in homocysteine remethylation through betaine-homocysteine methyltransferase pathways.
PMCID: PMC8224793
Choline, betaine, and homocysteine metabolism
Review discussing choline conversion to betaine and its role as a substrate in the betaine-homocysteine methyltransferase reaction.
PMID: 20446114
Riboflavin and MTHFR-related methylation pathways
Human study evaluating riboflavin’s role in homocysteine metabolism in individuals with the MTHFR 677TT genotype.
T polymorphism” rel=”noopener” target=”_blank”>PMID: 16380544